USyd

Fight Tumour Blindness!

A web-based registry for ocular melanoma that will collect high quality clinical and pathology data from patients, evaluate the outcome of local (conservative) eye saving treatments and stratify patients for appropriate emerging therapies to combat potentially fatal systemic disease.
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Ocular Melanoma

The SSR module for Ocular Melanoma was launched in September 2018.

This project will develop an Australian first: a web-based registry for eye melanoma that will achieve the following:

  1. Collect high quality clinical and pathology data from patients.
  2. Evaluate the outcome of local (conservative) eye saving treatments.
  3. Stratify patients for  appropriate emerging therapies to combat potentially fatal systemic disease.

The project seeks to improve health outcomes by fundamentally embedding research within health care delivery, a clear recommendation of the McKeon Strategic Review of Health and Medical Research, 2013.

Melanoma of the eye represents a threat to the patient’s vision and life. The eye is the second most common site of melanoma after the skin. Current treatments, although often successful, may reduce vision or result in loss of an eye. Uveal melanoma is fatal in approximately 50% of cases due to spread of the disease (metastases). New treatments are becoming available to improve outcomes in quality of life and survival once eye melanoma is found to occur outside the eye.

Successful management of eye melanomas requires a multidisciplinary approach and detailed collection of diagnostic, treatment and follow up information. Cancer registries in Australia are currently state-based and collect only minimum information. The essential data required for understanding eye melanoma recurrence rates, metastases and treatment success is missing.

Currently, primary eye melanoma is treated conservatively if possible, to try and preserve the eye and vision, while effectively treating the eye tumour. There are many different approaches to treatment in Australia today. The most common treatment is plaque brachytherapy, using  iodine or ruthenium radiation, with-or-without customised plaque design and/or dosimetry planning. Other treatments commonly used include trans-scleral resection for anterior segment tumours and ciliary body tumours, as well as endo-resection of large posterior tumours.   Thinner tumours may be treated by laser using either transpupillary thermotherapy (for pigmented tumours) or photodynamic therapy (PDT).

Chief Investigator

Rod O'Day

MB BS, PhD, FRANZCO

Director of Research, Save Sight Institute
Dept. of Ophthalmology & Eye Health, University of Sydney
Chief Investigator and Innovator, Save Sight Registries